Which medication is generally not recommended for treating depression in pregnant patients?

Paroxetine is generally not recommended for treating depression in pregnant patients due to its association with an increased risk of congenital anomalies, particularly cardiac defects, when taken during the first trimester. The potential risks to the developing fetus must be carefully weighed against the benefits of treating maternal depression. While other medications, such as sertraline, bupropion, and fluoxetine, may still be considered and sometimes prescribed during pregnancy, paroxetine’s safety profile in this context warrants caution.

In making medication choices for pregnant patients, healthcare providers prioritize those with a more favorable safety record. The implications of using paroxetine during pregnancy necessitate thorough risk-benefit discussions with patients, highlighting the importance of selecting alternative antidepressants when possible.