What is the spectrum of Flucloxacillin?

Flucloxacillin is classified as a narrow-spectrum antibiotic, specifically effective against certain gram-positive bacteria, most notably Staphylococcus aureus (particularly penicillinase-producing strains). Its pharmacological action centers on inhibiting bacterial cell wall synthesis, making it a potent choice for treating infections caused by susceptible strains.

This classification as narrow spectrum means that flucloxacillin is not effective against a wide range of pathogens, particularly gram-negative bacteria, which are typically resistant to penicillins. Instead, flucloxacillin is primarily used for infections where staphylococcal bacteria are suspected or confirmed, such as skin and soft tissue infections, and certain respiratory tract infections. Understanding this specificity is crucial for appropriate antibiotic selection to treat bacterial infections while minimizing the risk of developing antibiotic resistance.