What is a contraindication for the use of NSAIDs in pregnant patients?

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy is approached with caution due to their potential effects on both the mother and the fetus. One significant contraindication for NSAIDs in pregnant patients is that they may increase the risk of uterine contractions. This is particularly relevant during the third trimester, where there is a concern that NSAIDs can inhibit the synthesis of prostaglandins, which play a crucial role in maintaining pregnancy and facilitating labor.

Prostaglandins help keep the cervix soft and promote uterine contractions; therefore, their inhibition could potentially lead to complications. Additionally, NSAIDs have been associated with other risks during pregnancy, including possible effects on fetal cardiovascular function and kidney function.

In contrast, discussing headaches as a side effect does not highlight a specific contraindication for the use of NSAIDs in pregnancy. Furthermore, stating that NSAIDs are safe for all trimesters is misleading, as their safety profile changes throughout pregnancy. Thus, option B accurately reflects a critical concern regarding the use of NSAIDs — they can indeed increase the risk of uterine contractions during pregnancy, especially later in the gestation period.